Dopamine-derived tetrahydroisoquinolines. Novel inhibitors of dihydropteridine reductase.

نویسندگان

  • R Shen
  • R V Smith
  • P J Davis
  • A Brubaker
  • C W Abell
چکیده

Dopamine-derived tetrahydroisoquinolines, such as 3',4'-deoxynorlaudanosolinecarboxylic acid, higenamine-1-carboxylic acid, higenamine, and salsolinol, inhibit human liver dihydropteridine reductase noncompetitively with Ki values ranging from 1.5 to 90 microM. The enzyme is also inhibited noncompetitively by dopamine (Ki = 6 microM) and aminopterin (Ki = 100 microM) but uncompetitively by phenylpyruvic acid (Ki = 6.5 mM). These alkaloids may alter monoamine metabolism in mammals by inhibiting dihydropteridine reductase.

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عنوان ژورنال:
  • The Journal of biological chemistry

دوره 257 13  شماره 

صفحات  -

تاریخ انتشار 1982